Latest News Bulletins
Seat Bones from the Horse's Side of the Saddle
By Nancy Wesolek-Sterrett
Dressage Department Head, Meredith Manor International Equestrian Centre
When a horse has trouble moving straight or difficulty bending in one direction or another, or the rider cannot circle without pulling on the inside rein, the first thing I think of is not, “What’s wrong with this horse?” I consider that the crookedness may be feedback and immediately check the rider’s position. Is she sitting up straight?
Sitting straight means that the rider is centered over the horse’s center of gravity with equal weight on both seat bones. As well as, the rider’s shoulders directly over the seat bones. This is important because unless a rider can sit this way, she will not be able to subtly modify those seat bone pressures correctly to communicate direction, bend, speed and other information to her horse. When the rider’s seat bones contradict other aids, the horse gets confused, crooked, or offers other feedback that telegraphs the message, “What did you say?”
At the halt, the horse’s spine should be straight from poll to tail. The rider’s nose, chin, breastbone, belly button and spine all align with the horse’s spine. From the side, the rider’s ear, shoulder, hip and heel should align. As the horse begins to move, the rider keeps equal weight on both seat bones to indicate a straight direction of travel. Or she weights and unweights her seat bones in nuanced ways that influence the direction of travel in bends, circles, canter leads, lateral movements, etc. To get a square halt, she needs to put her weight equally on both seat bones again.
If the rider pays attention, the horse broadcasts clear feedback about as to how he feels the weight distribution in her seat bones and what it suggest that he do with his body. Take the example of a crooked rider whose default position puts more weight on her left seat bone than on her right. When going to the left, the horse probably bends and circles correctly. However, when the rider asks the horse to circle right, the horse may drift out to the left, fall in through the right shoulder, or have difficulty picking up the right lead. Ridden continually this way, the horse may develop more muscle on the left side to carry the rider’s crooked weight and become asymmetrical in the pelvis or hips.
Small things can make a huge difference for the horse. I recall one horse whose rider trained him correctly to turn on with the rider’s weight slightly heavier on the inside seat bone. He was sold to a rider who used a ‘spiraling seat’ to turn her horse. While this is very useful seat imagery, the rider misunderstood the full concept and overturned her shoulders, pushing her weight onto her outside seat bone. The horse was confused and the new rider was frustrated. (Sit on a swivel chair and try it.)
If rider sits heavily on the left seat bone, horse may dive to right or may drift to left to get more underneath the rider. The horse may have difficulty getting the right canter lead, refuse to yield from the right leg because the left seat bone is blocking the request. A jumper may run out to the left in front of a jump or drift to the left on landing. Unequal weight may put a lazy horse behind the leg and slow him down. Given confusing signals, a hot horse might get hotter and run from the pressure.
Understanding how to sit with equal weight on both seat bones, understanding how to weight and unweight each seat bone independently of the other, and keeping shoulders aligned with the hips can make many riding problems go away. A very slight shifting of weight onto one seat bone or the other can help the horse give the right answer as he follows the rider’s weight. For example, when the rider starts from the halt sitting straight with equal weight in both seat bones, she can give the horse clear communication when they start circles and eventually lateral work. Later on in the training scale, the rider’s ability to shift slightly from one seat bone to the other while staying straight and centered over the horse’s spine is essential to correct flying changes.
Many riders blame the horse when he goes crooked rather than considering that he may be giving them feedback about their own crookedness. A horse may act out because of a sore back and the rider may blame the saddle instead of realizing that continual riding with her seat bones unequally weighted could be the cause.
The question “Is it me or is it my horse?” can be hard to answer when you ride the same horse all the time. The rider with just one horse will benefit from the help of an instructor or experienced observer who can give them feedback about whether the rider’s crookedness is making the horse crooked or vice versa. Gradually, both horse and rider can develop a feel for ‘straight’ and help each other stay centered. Our students have the opportunity to test their seat skills by riding horses of all sizes, personalities and training levels. They learn a lot from their mounts as they adjust to these differences.
Riders with their own horse might take lessons on other mounts from time to time to help them figure out, “Is it me or is it my horse?”
Certainly a horse with unevenly developed musculature, saddle soreness, teeth issues, or dozens of other major or minor issues may compensate in ways that put the rider crooked in the saddle. Regardless of the cause, however, if the rider matches the horse’s crookedness, it will never go away. The rider that becomes responsible for being ‘straight’ herself, helps her horse feel what ‘straight’ should be so that he can figure out how to get there.
Riders ambitious to get to the next level in their sport sometimes hope that buying a horse that is at or above that level is the way to move up. Once they are in the saddle, however, they find themselves stuck right where they were. Worse yet, the higher level horse they thought would be their ticket to ribbons winds up ‘dumbing down’ its performance to the rider’s lower level. Often, the problem is very basic. The rider has never really learned how to sit truly straight with equal weight on both seat bones.
The seat bones are literally the seat of all communication with the horse. Correctly or incorrectly they are always sending information to the horse. Riders who pay attention to their seat bone messages and the feedback their horse gives about them will become able to truly influence their horse stride by stride. Remember, nothing replaces a correct, independent, influencing seat.
What to expect when she’s expecting: Foaling 101
Part I – Managing the late pregnant mare and preparation for foaling
Foaling season is an exciting time of the year for both veterinarians and breeders. For first time breeders the pregnancy, foaling, and neonatal periods can be stressful, as they should be. Proper care for the pregnant mare and appropriate preparation for foaling and potential complications are key in an uneventful foaling and healthy newborn. This guide is meant to be an overview of some key components and to allow the expecting horse owner to develop a plan and questions for their veterinarian. It is not meant to be an exhaustive checklist, so we encourage you to consult with your veterinarian with plenty of time before foaling is expected.
Normal gestational length in the horse can be highly variable, but is 330-345 days on average. There are a wide variety of causes of a longer gestational length. Some mares tend to carry foals longer than average, and some may consistently carry foals out to a year or longer. Mares that are due earlier in the year typically carry foals longer than those due in the late spring, which is thought to be due to photoperiod (the amount of time in the day the horse is exposed to sunlight). Some pregnancy abnormalities may also lead to longer pregnancies, including dysmaturity (a foal that is less mature than what it should be for a given gestational age) or a previous twin that resulted in slowed development of the remaining foal. It is very rare for a long gestation foal to be large enough to cause dystocia (a difficult birth), and typically long gestational lengths are required for adequate development of the foal and preparation for life outside the mare. Rarely is it a good idea to induce labor in a horse, so taking advantage of ways to predict foaling will help to reduce the number of sleepless nights the owner has to endure! Foals born before 320 days gestation are considered premature and may face a variety of hurdles, so if foaling is looking imminent in a mare that hasn’t neared her due date, notify your veterinarian immediately as a team approach will be required for any chance of survival of the foal.
Early in pregnancy management of the mare can typically continue as normal. Vaccinations and deworming should be kept up to date, and teeth floating should be performed regularly to ensure the mare can maintain adequate nutrition through pregnancy and lactation. Typically their caloric intake does not need to be increased significantly until around the last month of gestation, when they are going to begin lactation. However, it is important to maintain mares in adequate body condition (around a 6/9 on the body condition scoring system). The major changes to vaccinations early in pregnancy are the type of vaccine. Typically pregnant mares should be vaccinated with killed vaccines or those tested and approved for use in pregnant mares. Be sure to tell your veterinarian if your mare is pregnant so they can choose the appropriate vaccines.
Later in pregnancy some additional vaccinations are recommended to protect the foal both before and after birth. One significant concern in pregnant mares is equine herpes virus-1 (EHV-1) which can cause late-term abortions or significant disease in the newborn. Vaccination of the mare for EHV-1 is recommended at 5, 7, and 9 months of gestation to prevent disease or abortion. In addition, antibodies are key proteins involved in preventing disease in all animals by binding to pathogens, and foals are born with extremely low levels of circulating antibodies due to the type of placenta present in the horse. The early immune system of the foal relies heavily on antibodies that they gain by ingesting colostrum, or the mare’s first milk, within the first 24 hours of life when their gut can absorb these intact large proteins. By vaccinating the mare for EEE/WEE, tetanus, WNV, and other pathogens (as deemed necessary by your veterinarian) approximately 4-6 weeks prior to the expected foaling date, antibodies for these pathogens will be produced and present in high concentrations in colostrum, thereby protecting the foals against these diseases. In addition to the mare’s standard vaccines, rotavirus vaccination is recommended in the last couple months of pregnancy as well. This is a virus that does not affect adult horses, but is a common cause of diarrhea in youngsters. By vaccinating the dam late in pregnancy it will increase antibodies against this pathogen in the colostrum, thereby conferring protection to the foal.
A wide variety of cues can lead us to predicting when a mare is going to foal. Obviously, having an exact ovulation date with confirmed pregnancy off of that cycle is ideal. If an exact date of conception is not known, some fetal measurements, including ocular or aortic diameter, can be measured using transabdominal ultrasound by your veterinarian and used to estimate gestational age. These tend to become more sensitive as pregnancy progresses, but it can become more difficult to locate these structures transabdominally as the fetus gets larger depending on its location in the mare’s abdomen. Below are some other changes to monitor that can indicate when she is getting closer to foaling.
- Around 1 month before foaling the mare’s udder will begin to show some enlargement, and you can get some watery milk out of it.
- About 2 weeks prior to foaling you will notice relaxation of the pelvic ligaments. You will notice that the muscles and ligaments of the hindquarters, tail head, and perineum will begin to soften. Her hindquarters may begin appearing more sunken.
- 1-2 weeks prior to foaling you will see significant enlargement of her udder. As she gets closer to parturition the milk present in her udder will become thicker and more yellow in color. This is the transition to her producing colostrum. This is the antibody rich milk that will provide foals with the essential components to an early healthy immune system. Some mares, particularly multiparous mares (those who have had multiple foals) may leak colostrum prior to foaling. If you notice this occurring during this period, be sure to notify your veterinarian and save as much as you can in the freezer to ensure that the foal has a colostrum stock that can be fed immediately after birth
- In the 24-48 hours prior to foaling a variety of changes occur. The first that you may notice is the udder will “wax” over with a bead of colostrum as it gets thicker just before foaling. In addition, milk calcium can be measured daily with a variety of commercial kits. The milk calcium will increase to greater than 10mmol/l when the mare is within 48 hours of foaling.
Preparing the Foaling Area and Mare
The foaling area should be prepared about 4-6 weeks prior to the expected foaling date, and the mare should start being put in there to allow her to get used to the area and prevent any “surprise” foalings in a less-than-ideal area. Foalings can occur either indoors or outdoors, and there are pros and cons to each. Whether it is going to be inside or out, the major considerations are having an area that is clean, dry, and free of hazards. For outside foalings, this means a wide open area where the mare is by herself. There should be no standing water, hazardous fencing, or bushes/trees that could pose a threat to the newborn foal. For indoor foalings, a large (at least 12x12) stall with straw bedding is important.
A few considerations for the mare should be addressed at this time, well in advance of the anticipated foaling date. If the mare has had a caslicks procedure, this should be opened about 1 month prior to foaling. In addition, neonatal isoerythrolysis (NI) is a potential risk that should be screened for in mares that have had multiple foals or received any blood products (whole blood, plasma) in the past. NI results when the mare possesses antibodies against the foal’s red blood cells. When the foal ingests colostrum, these antibodies will cross the gut and gain access to the foal’s blood stream, allowing incompatible antibodies to attack the foal’s red blood cells. The mare will only develop antibodies against these different blood groups if she has been exposed to them in the past, so it is only a risk if the mare has had previous foals or been exposed to different blood groups due to blood products. Horses have a large number of blood groups, but the groups Aa and Qa are the 2 that tend to cause NI reactions. At risk mares should be tested for antibodies against these blood groups prior to foaling to determine whether additional steps need to be taken to avoid a problem in the foal.
Foaling monitoring systems will help the anxious horse owner get a bit more sleep during this stressful time, help reduce anxiety in both the owner and mare, and make for a more natural and undisrupted birth. Many farms have cameras in foaling stalls and a closed circuit TV set up elsewhere in the barn or a nearby house so someone can be sleeping there and periodically wake up to check the camera without going into the barn and disrupting the mare. In addition there are a wide variety of systems that will send alerts when they detect a mare is going into labor. These include systems that monitor how the mare is laying down, sweating, or separation of the vulvar lips and will send a signal to selected people when labor has started. These foal monitoring systems should start being utilized if you begin to see signs of imminent parturition, or around a week or so before the expected foaling date as some mares will not give you much notice.
Stay Tuned for Part II of Foaling 101 coming next month!
If you have any questions regarding foaling or any medical issues affecting your horse, please contact your veterinarian or the veterinarians at New England Equine Medical & Surgical Center.
Erica Secor, DVM
Jacqueline Bartol, DVM, DACVIM
What to expect when she’s expecting: PART II
What to expect when she’s expecting: Foaling 101
Part II – Foaling and the Early Neonatal Period
The day has arrived… Your mare is looking like she is about to pop, and you are sure foaling is going to happen tonight. Knowing the normal progression of parturition and the immediate post-foaling period will be pivotal to ensuring a healthy foal. By having a thorough understanding of normal foaling, you will be able to more easily identify when something is amiss and in need of veterinary attention. Normal labor in horses progresses very quickly, so early intervention is required if a problem arises.
The Stages and Normal Progression of Labor
Stage I of labor can take minutes to hours (generally an hour or two, but it can be up to four). Often the mare will appear to be colicky. They often pace, look at their sides, will get up and down frequently, and urinate often. During this period the foal will be turning to the correct foaling position, which involves it’s front feet extended towards the cervix and their head between their front legs. Uterine contractions begin during this stage, which causes much of the discomfort. In addition, cervical dilation is occurring during this time, which is essential for uncomplicated foaling. Horses are one of very few species that can halt labor early in this stage if they feel threatened, so it is very important to not disrupt the mare during this period or you can expect to be up another night! If she isn’t already, be sure to put the mare in the foaling area during this time. In addition you can wrap the mares’ tail with brown gauze to minimize contamination of the foal during labor. Depending on how far away your veterinarian is located and how comfortable you feel with the foaling process, you may want to notify your veterinarian at this time. This should be discussed with your veterinarian ahead of time.
Stage II of labor begins when you see her water break (which is due to rupture of the chorioallantois portion of the placenta and release of allantoic fluid). This stage should progress very quickly (no more than 30 minutes) and is associated with significant pushing by the mare. After the water breaking you will see the white amnion surrounding the foal. You should be able to see two front feet followed by the foal’s muzzle at the level of their knee. Often the mare will get up and change positions periodically during this phase. In addition, once the foals’ hips are engaged in the pelvic canal the mare will often stop pushing for a period to rest, then finish delivering the foal. Once the foal's nose is delivered, break the white amnion if it hasn’t already broken, and clear the fluid and membrane from around its nose by massaging the nasal passages a few times and pushing the fluid out. Then as long as everything is progressing normally, you should step back and let the mare do the work. Resist the urge to pull the foal if all is going well, as it can result in trauma to the mare or foal as well as premature umbilical rupture. Once the foals chest is delivered ensure the foal is breathing on its own, even if the mare takes a break. If there is any concern about the foals viability, ensure the nose is clear first, then rub the foal briskly with towels. Often this is enough to stimulate breathing on the foal’s part and will help dry them off and warm them up. Once the foal is delivered and everyone appears happy and healthy, give the mare and foal some time alone to bond. This period is very important for maternal bonding, and is often forgotten as everyone is excited about the new foal. Within two hours, and more typically in the first hour, the foal should be up and nursing.
Stage III of labor is expulsion of the fetal membranes, aka the placenta. This should be completed within three hours after birth, and the mare is put at significant risk of infection and serious illness if she experiences a retained placenta. Do not wait to contact your veterinarian if you suspect she has a retained placenta, as early intervention is key. Be sure to save the placenta for examination by your veterinarian. They will look closely at the placenta to ensure that it is intact, for any evidence of placentitis, or indication of placental insufficiency.
These stages are summarized with a “1-2-3 rule”. This makes the general timeline of events easier to remember. The foal should be delivered within 1 hour of the beginning of stage II labor. Within 2 hours of birth the foal should be up and nursing on its own. The placenta should be expelled in its entirety within 3 hours after birth. By keeping this rule in mind you can more easily decide if a foaling is progressing in a timely fashion.
With horses being the fragile creatures they are, it’s amazing that most foalings go as smoothly as they do. However, if problems should arise they need to be dealt with promptly to give the mare and foal the best chance at survival. We recommend learning as much as you can about what to do in a foaling emergency before the situation should arise so you can be as prepared as possible.
“Red bag”, or premature placental separation: In a normal delivery the red chorioallantois ruptures, resulting in the “water breaking” and you see the white amnion directly around the foal. If the chorioallantois separates from the uterus prematurely it will not rupture. The result is that you see a red, velvety membrane first instead of the white amnion. Since this is caused by premature separation of the placenta from the uterine wall, the foal becomes oxygen deprived during delivery. If you see this, you have to immediately rupture the sac and pull the foal out. The easiest way to do this is with a sharp pair of scissors, so be sure you have a clean pair in your foaling kit. Since it is difficult for the foal to breathe on its own until its thorax is through the birth canal, you will have to help deliver the foal as quickly as possible until it is to a point where normal respiration is possible.
Dystocia, or “difficult birth”: This refers to any birth that is difficult or prolonged due to poor positioning of the foal, anatomic abnormalities in the mare, or congenital defects resulting in an inability for the mare to deliver the foal normally. Normal foal position is front feet and nose first, in a “diving position”. A breech birth, or when they come hindquarters first, is particularly important to deal with and resolve quickly, as the umbilical cord will be compressed prematurely as it enters the pelvic inlet, resulting in oxygen deprivation to the foal. The most common cause for simple dystocia is shoulder lock, and is something that most owners can deal with quickly. The widest point of a foal is at their shoulders, and they frequently become stuck in the pelvic canal at this point. To resolve this, gently pull one forelimb at a time in synchrony with the mare’s contractions. This will help to pull one shoulder through at a time. If they get caught at the foal’s hips, you can try rotating the foal 45* to have them align diagonally with the mare’s pelvis, which is the widest point of the pelvic canal.
Times to Call Your Veterinarian Immediately
There will be some obvious foaling emergencies that require immediate veterinary attention. However, there are some situations where the foal may appear healthy, but urgent care can prevent serious consequences.
- Dystocia or red bag delivery, even if the foal is alive and out: these foals often have experienced some degree of oxygen deprivation, depending on how severe the dystocia and how prolonged the delivery was. Hypoxemic-ischemic encephalopathy (HIE) also known as "Dummy Foal Syndrome" is a potential consequence of oxygen deprivation in utero or during delivery, and may not manifest until hours to days after birth. However, preemptive steps may be taken to prevent complications, and serial neurologic assessments will be important to catch any problems early.
- Meconium staining of the foal and/or placenta: if there is any evidence of dark meconium (first manure) during delivery the foal should be assessed immediately. These foals are at high risk to develop aspiration pneumonia, and early treatment will be key for survival
- The inability to stand and nurse on their own within 2 hours (most normal foals are able to accomplish this within an hour): this can be an early sign of problems, including HIE or sepsis. While they often look too leggy and uncoordinated, normal foals will be able to get through the uncoordinated phase quickly and be able to get up and down on their own.
- Evidence of broken ribs: broken ribs are fairly common in foals, as their shoulders are tight through the pelvic canal and their elbows can press in with extreme pressure, resulting in rib fracture. Unfortunately the most common site is directly over their heart. Any foals that have swelling, soreness, crackling sounds, or you can feel crepitus (a rough feel of the bone ends moving over each other) should be evaluated quickly by a veterinarian to ensure there is no damage to the underlying structures or an imminent risk of the fractures causing injury to the heart or lungs. Foals that are suspected to have rib fractures should be handled with extreme care to not cause further shifting of the fracture ends.
All postpartum mares and newborn foals should be evaluated by a veterinarian about 12 hours after birth. The mare should be evaluated for any injuries and general health and condition. The placenta should be closely inspected for any evidence of placentitis, placental insufficiency, or incomplete expulsion. The foal should be evaluated for any congenital abnormalities and general health. In addition, blood should be drawn at 12-18 hours of age to test for IgG concentrations. This is a measure of the antibodies absorbed from colostrum. Inadequate IgG results in failure of passive transfer and needs to be addressed quickly by administering further colostrum (if the foal is less than 24 hours old, when they still absorb antibodies from the gut) or intravenous plasma (if the foal is greater than 24 hours old). The umbilicus should be evaluated thoroughly, and dilute chlorhexadine should be used to dip the umbilicus a few times a day for the first 3-5 days of life.
Foaling season is an exciting time for any horse owner, but much anxiety can be reduced by taking the appropriate steps ahead of time to ensure you are well prepared for potential complications. Specific steps to take and what is applicable for your situation should be discussed early on with your veterinarian, so you both have a good game plan for when that day comes.
Some good resources for expecting owners
- The Complete Book of Foaling: An Illustrated Guide for the Foaling Attendant by Karen E N Hayes DVM MS
- A foaling guide from the Veterinary School at Kansas State University http://www.vet.k-state.edu/VHC/equine/pdf/Foaling_guide.pdf
If you have any questions regarding foaling and what to expect or questions about any equine health issue please speak with your veterinarian or any of the veterinarians at New England Equine.
Erica Secor, DVM
Jacqueline Bartol, DVM, DACVIM
Does my horse need shoes?
Are horses meant to wear shoes? Are they meant to be barefoot like the horses of the wild? This is a very popular question in equine husbandry today and there are very good arguments on both sides of the table. Some argue that shoes hinder the circulation and sensation of the foot, while others argue that the equine foot requires support and protection to function properly. Whatever your preference, it is truly important to recognize that theories are like shoes....one size does not fit all.
The equine hoof is a complex structure which encases the distal bones of the limb and a number of soft tissue structures. Any one of the structures involved with the foot can be a source of pain or lameness. The hoof wall is meant to do the majority of the load bearing with some pressure being transferred to the sole. The sole itself is a sensitive structure and will become painful if forced to become the primary load-bearing structure. This generally happens when the wear on the dorsal horn exceeds the growth. This is one reason we choose to apply a shoe. This is a universal problem which dates back centuries and crosses many cultural boundaries.
There are many examples of shoes going back to the days when the horse first starting being used for riding and draft around 1580 B.C. The first shoes were made of woven grass and reeds tied on the foot. The Egyptians used animals skins as shoes to protect their horses' feet and the Romans created a "hipposandal" which was a leather sandal with an iron sole. The swift movement of Genghis Khan's armies are partially attributed to a rawhide "cup" for the feet which aided in the swift movements of his armies. China is credited with developing the first iron shoe, but traditional shoeing with nails is thought to date back to 5th or 6th Century B.C. with the Greeks and the Romans. The Romans reportedly had horseshoes with nails when they invaded England in 55 B.C. William the Conqueror (1066 A.D.) was credited with popularizing the practice of shoeing horses in England. History tells us that protecting the horse's foot is paramount to the continued use and soundness of the animal.
We must keep in mind though, shoes are not innocuous. Horseshoes can be a source of pain and discomfort to an animal when inappropriately selected or applied and they can constrict the natural expansion and contraction of the foot. The growth and circulation of the foot is tied to that movement and can be compromised by poor shoeing/trimming practices. That is why it is important for you, as an owner, to ensure that your horse is kept on an appropriate shoeing cycle and that the feet are trimmed regularly because this minimizes the negative effects that shoes can have on the feet. At the same time, if your horse does not need additional protection for his feet, he may be better off barefoot. Shoes are sometimes used for purposes other than protection though.
Shoes can be used to compensate for various conformational deficits or pathologic processes which might otherwise cause lameness. Variations in the size or shape of a horse's foot in relation to the conformation and size of the horse can have serious effects on the animal's long term comfort and soundness. If we can detect problems early and apply corrective shoeing or trimming techniques we may be able to alter the course of disease or minimize the long term effects of a condition rather than allowing it to progress unchecked.
The most important thing to do is use common sense when making a case for or against shoes. Just because the words "wild and natural" sound appealing, they don't necessarily offer a universal solution. If your horse is comfortable barefoot, there may be no need to put shoes on him. But if wear exceeds growth or there is a pathologic condition which needs to be addressed, look at the options. Good farriers take a great deal of pride in their work and want your horse to be comfortable and sound. Many attend regular continuing education and are willing to explore reasonable options to keep your horse happy and healthy. Discuss your ideas or concerns with your farrier and/or your veterinarian. Remember that good shoeing techniques have taken centuries to develop and it takes many years to be able to master those skills. You may not need to change anything with your horse if he is happy and sound, but if not, do your homework. Good farriers, trimmers and vets should take the time to answer your questions and help you find a solution which is right for your horse.
If you have any questions regarding trimming and shoeing your horse, please consult with your veterinarian, or farrier, or any of the veterinarians or farriers at New England Equine Medical & Surgical Center.
Elizabeth (Betsy) Lordan, DVM
Jacqueline Bartol, DVM, DACVIM
IRAP, PRP, MSC, OMG! The use of biologics in lameness treatment
The world of lameness treatment options has grown considerably in the last decade through the introduction of various biologics. To the average horse owner, the various acronyms that go along with these can be daunting enough, let alone understanding the processing and use of them. The methods discussed here are all considered autologous biologic agents, meaning that they are derived from the patient in question. The processing allows these normal factors and cells found in the body to be concentrated or converted to products that can have potent effects when administered to a local area. These therapies are becoming more widespread, and additional uses for them are becoming apparent.
Interleukin-1 β Receptor Antagonist Protein (IRAP):
Interleukin-1 β (IL-1β) is one of the major pro-inflammatory mediators found in healthy and diseased horses. This protein is released from a variety of cells and will help incite inflammation. There is also a protein in the body that will bind IL-1β and inhibit its function, thereby reducing inflammation. This protein is termed Interleukin-1 β Receptor Antagonist Protein, or IRAP. We now have ways to induce white blood cells to produce IRAP and can concentrate the protein. This concentrated form of IRAP can then be injected into injured or osteoarthritic areas to help reduce local inflammation and can help support regeneration as well. While IRAP will not completely prevent osteoarthritis from developing, it can help support a healthy joint environment and delay the onset of changes.
IRAP therapy involves drawing 50-60ml of your horse’s blood into a special syringe, and this is transferred to a tube containing special glass beads that will stimulate the white blood cells to produce IRAP. The blood is incubated in this manner for 24 hours, then the serum portion is taken and either used immediately or can be frozen for future use. One blood draw typically produces enough serum for 6-7 treatments. IRAP is most often used in early osteoarthritis or following joint surgery to reduce inflammation and prevent osteoarthritic changes. However, we have also begun using it with some tendon and ligament injuries as well to reduce the local inflammatory response.
Platelet-rich Plasma (PRP):
Platelets are a natural component to blood, and most often thought of for their role in clotting secondary to injuries. However, platelets carry a wide variety of growth factors which will induce white blood cell infiltration to an area to induce blood vessel, connective tissue, and skin regeneration. One benefit of PRP over other therapeutics is the wide variety of factors that it provides, compared to just one. This can help to assist the healing response from a variety of angles.
Blood is taken from your horse and is centrifuged in a special container to separate it into red blood cells, platelet poor plasma, and platelet rich plasma (PRP). The PRP is separated from the remaining blood products. Immediately before use, the PRP is activated using one of a variety of methods, which will cause it to form a platelet clot. This is then injected or applied to the site of interest. Most commonly PRP is used in tendon or ligament injuries, which often have difficulty healing due to poor vasculature, which PRP helps to combat by recruiting new blood vessel formation and collagen production. It is also used in wound and bone repair, and only recently is being used within joints.
Mesenchymal Stem Cells (MSC):
Mesenchymal stem cells are derived from bone marrow, adipose tissue (fat), or umbilical cord blood, with bone marrow or fat derived cells being the most commonly used in equine practice. Stem cells have the ability to regenerate tissue, however this has only been shown with certain tissues and mostly in research settings. In addition, stem cells have the ability to release a wide variety of growth factors and anti-inflammatory proteins.
Bone marrow requires about 3 weeks to process the stem cells and return them to the clinic, while adipose derived can be turned around much quicker (2-3 days). There is some evidence that bone marrow derived stem cells may show more benefit than adipose derived in some circumstances, but the tissue of choice is clinician and case dependent. MSC’s generally are able to exert their maximum effect early on in the disease process. Stem cells have been used successfully in a variety of clinical disorders involving bone, tendon, and ligament.
The use of these biologics in lameness treatment, as well as management of other disorders, is only recently becoming commonplace. There are many intricacies in case selection, but these options can serve as valuable tools in lameness management and should be discussed with your veterinarian to determine whether they may be useful in your horse.
Please call your veterinarian or the veterinarians at New England Equine Medical & Surgical Center with any questions about the management of lameness in horses.
Erica Secor, DVM
A. Rachel Roemer, DVM
Touchstone Farm is Site for Post-Traumatic Stress in Youth
Touchstone Farm, in Temple, NH, is the site of a research study on the effect of equine-facilitated psychotherapy (EFP) on symptoms of post-traumatic stress (PTS) in adolescent boys. Researchers from the Cummings School of Veterinary Medicine at Tufts University and from Washburn University in Topeka, KS, are partnering with Touchstone Farm and the Wediko School in Windsor, NH. The Horses and Humans Research Foundation awarded the $50,000 grant to fund the study.
Megan Mueller of Tufts and Leslie McCullough of Washburn are the principal investigators for the research. Boo Martin, Executive Director of Touchstone Farm, and Winter Keeler, who is both Senior Clinical Supervisor at Wediko and Manager of Horse Power Therapeutic Horsemanship at Touchstone Farm, will implement the EFP sessions at the farm. A select group of Horse Power volunteers will participate in all the sessions, with each volunteer working one-on-one with a horse/client pair.
Five Wediko students, adolescent boys assessed to have symptoms of post-traumatic stress, will participate in 10 weekly EFP sessions that include both mounted and unmounted work with horses, while receiving psychotherapy at Wediko. A control group of five boys who also have symptoms of PTS will receive psychotherapy at Wediko but will not participate in the EFP sessions. Touchstone Farm will run multiple 10 week sessions so that a total of 30 boys will participate in equine-facilitated psychotherapy at the farm with corresponding control groups at Wediko.
“EFP has been shown to be effective in reducing children’s anxiety over attending therapy and in treating emotional and behavioral challenges,” says Mueller. “However, we need additional research on the efficacy of equine based psychotherapy in addressing the needs of youth who have experienced trauma to support evidence based practice in this field.”
The first EFP session begins in February. Throughout January, Touchstone Farm staff and volunteers will continue preparations for the research. This includes additional training for volunteers as well as training for the horses who will be paired with Wediko clients. Touchstone Farm has a large pool of riding and driving horses already trained in therapeutic horsemanship. The additional training will enable Martin and Keeler to select the horses who are most willing and able to partner with adolescent boys coming to grips with past trauma and help them move ahead.
Touchstone Farm, home of Horse Power and Pony Farm, is a non-profit educational and therapeutic organization that fosters a community of belonging for people of all ages, abilities and backgrounds. Touchstone Farm offers a rich and challenging variety of experiences, which includes summer camps, able-bodied and therapeutic horseback riding and carriage driving lessons, an instructor training school, and equine-related specialty weekends. Grounded in a sense of place, mutual respect and well- being, the 28-acre farm is a sanctuary that nurtures connections, cooperation, self-confidence, and personal growth.